The FP receptor is the least selective of the prostenoid receptors in that it is responsive to PGD2 and to a lesser extent PGE2 at concentrations close to those of PGF2α. Standard prostanoids have the following relative efficacies as receptor ligands in binding to and activating FP: PGF2α>PGD2>PGE2>PGI2=TXA2. In typical binding studies, PGF2α has one-half maximal binding and cell stimulating actions at ~1 nanomolar whereas PGD2 and PGE2 are ~5- to 10-fold and 10-100-fold … WebbProstaglandin F2-alpha (PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction …
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WebbProstaglandins are thought to stimulate the synthesis of matrix metalloproteinases 6 that subsequently dissolve the extracellular matrix of the ciliary muscle, thus reducing IOP by enhancing uveoscleral outflow. 7 For unknown reasons, prostaglandin analogs have relatively poor corneal penetration, 8 and their efficacy was reportedly reduced in … Webb9 okt. 2024 · PROSTIN F2 ALPHA is a drug product by PFIZER CANADA ULC, authorized by Health Canada. The drug identification number (DIN) is 00318736. Drug Informatoin. … locked door clip art
IJMS Free Full-Text Prostaglandin F2α Regulates …
WebbDescription The cAMP Gs cell line overexpresses a wild-type GPCR coupled with natural Gs, and is designed to detect the increase in intracellular cAMP levels in response to stimulation by receptor agonists.These cell lines are designed to be used in conjunction with the cAMP Assay test kit. Features Tag: None Agonist/Ligand: Beraprost Cell Types WebbHormones play an important role in the regulation of reproductive behavior. Here, we examined the effects of the fatty acid derivative prostaglandin F2 alpha (PGF2) on … WebbFunction Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second … indian supermarket manchester