WebHigh-density oligonucleotide arrays have been shown to be well suited to this task11–14, allowing the simultane-ous monitoring of all yeast genes15–17, all Escherichia coligenes, tens of thousands of human and mouse genes and selective sub-sets of genes from a wide range of organisms. Oligonucleotide arrays for expression monitoring are ... Web19 de set. de 2003 · High-density oligonucleotide arrays (1, 2) have revolutionized the study of gene expression.The technology enables researchers to detect and quantify tens of thousands of transcripts in a single experiment and has become a standard for the discovery of gene functions, drug evaluation, pathway dissection, and classification of clinical …

A Comparison of Normalization Methods for High Density Oligonucleotide ...

Web24 de mai. de 1994 · These probe arrays, or DNA chips, can then be applied to parallel DNA hybridization analysis, directly yielding sequence information. In a preliminary … Web1 de jan. de 2002 · High-density oligonucleotide arrays (gene chips): The probe is generated in situ on the surface of the matrix. The leader in these arrays is Affymetrix … macbook pro orange discoloration

DNA microarray - Wikipedia

WebWe have developed an approach that is based on hybridization to small, high-density arrays containing tens of thousands of synthetic oligonucleotides. The arrays are … Web1 de jan. de 2002 · The leading arrays in the category of high-density oligonucleotide arrays are manufactured by Affymetrix and utilize the combinatorial synthesis principle. The arrays are designed by using a light-directed chemical synthesis process that creates a series of photolithographic masks to define chip exposure sites, followed by specific … Web22 de jan. de 2003 · Motivation: When running experiments that involve multiple high density oligonucleotide arrays, it is important to remove sources of variation between arrays of non-biological origin. Normalization is a process for reducing this variation. costco petrol chester opening times