2024 Ezrin overexpression

Ezrin overexpression

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August undefined, 2024

WebJul 15, 2024 · For example, PDPN colocalizes with the ezrin, radixin, and moesin (ERM) family proteins, and binds directly to ezrin and moesin. In addition, overexpression of PDPN leads to phosphorylation of ERM proteins and activation of RhoA, thereby increasing motility and induction of epithelial–mesenchymal transition (EMT) [64,65,66]. WebJul 29, 2005 · The correlation between ezrin overexpression and the clinicopathological features of PDAC was evaluated using Chi-square test, and differences in survival curves were analyzed using log-rank tests. In results, ezrin protein is widely distributed in the cytoplasm and membrane of PDAC cells by IHC and IF staining, but some cases showed …

ACNP 60th Annual Meeting: Poster Abstracts P551 – P830

WebNov 4, 2013 · Ezrin overexpression was closely related with poor differentiation, late stage, and lymph node metastasis. Additionally, ezrin overexpression was associated with lower 10-year survival rate for patients with early stage cervical cancer, but not for patients with advanced stage. Aberrant localization and overexpression of ezrin might be an ... WebBackground: Ezrin is a member of the ezrin, radixin, and moesin family that provides a functional link between the plasma membrane and the cortical actin cytoskeleton. A correlation between ezrin overexpression and aggressive cancer behavior has been recently reported in various tumor types. albion pa grocery store

microRNA-211 regulates cell proliferation, apoptosis and …

WebJul 25, 2024 · The expression of Ezrin in colon adenocarcinoma tissues was screened by bioinformatics analysis and immunohistochemical assay. Si-RNA-mediated transfection and overexpression plasmid transfection were performed in colon adenocarcinoma cells. The proliferation viability was measured using MTT, colony formation, and EdU assays. WebFeb 1, 2024 · Both ezrin activation and overexpression are closely correlated with the progression of different types of cancers that are associated with MCI misregulation ( Table 1 ). For example, high expression of ezrin and phosphorylation of ezrin at tyrosine 353 are significantly associated with lymph node metastasis and poor prognosis in colorectal … WebOverexpression of ezrin appeared to promote a subtle change in moesin distribution, from a preferentially basolateral distribution (Fig. 9 D) to a more diffuse cytoplasmic staining … albion parent portal

Ezrin overexpression in gastrointestinal stromal tumors: an …

Modulation of membrane–cytoskeleton interactions: ezrin as …

WebAug 17, 2024 · Ezrin acts as a cross-linker between the cell membrane and the actin cytoskeleton. Ezrin is upregulated in various cancers and is associated with a poor prognosis (32, 33). Multiple studies have demonstrated that Ezrin overexpression in tumor cells increases their metastatic potential (19–22). Ezrin expression can be regulated by … WebFeb 12, 2024 · The overexpression of Ezrin promoted the migratory and invasive abilities of 22RV1 and PC-3 cells. Finally, the clinical data revealed that the expression of Ezrin in CTCs of PCa patients was significantly upregulated with the metastatic degree. albion pa 16401WebEzrin is a membrane bound cytoskeleton linker protein which has been associated with poor outcome in a number of cancers [75,76]. High levels of ezrin expression have been shown to correlate with higher grade tumors, decreased disease-free survival rate in pediatric patients, and had a greater risk of metastatic relapse [77–80]. albion ontario

"WebMar 4, 2024 · Overexpression of Ezrin promoted myoblast differentiation/fusion, inducing increased MyHC-I+ and MyHC-II + muscle fiber specialization, and the specific effects … " - Ezrin overexpression

Ezrin overexpression

The spatiotemporal matching pattern of Ezrin/Periaxin …

WebFeb 26, 2024 · An increasing amount of evidence indicate that Ezrin plays a central role in the development and progression of malignant tumours. … WebMay 11, 2024 · The ezrin/radixin/moesin (ERM) family proteins act as linkers between the actin cytoskeleton and P-glycoprotein (P-gp) and regulate the plasma membrane …

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WebStructure. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain an ERM domain.. Function. The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family.This protein serves as a linker … WebMay 1, 2004 · Therefore, rather than influencing only a single event, as do many other metastasis-associated molecules, ezrin overexpression might participate in many of the challenges that a proto-metastatic cell must overcome (Box 1). This suggests that ezrin and, by implication, other ERM proteins represent a crucial crossroad. Ezrin and cell-adhesion ...

WebDec 30, 2012 · Ezrin expression is responsive to estradiol and growth factors previously shown to be present in ovarian inclusions. These findings suggest that the microenvironment in ovarian inclusions and clefts contributes to the development of OVCA. Our findings elaborate on the mechanism of the ovarian origin of OVCA. Download to read the full … WebHere, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia …

WebFeb 14, 2010 · Ezrin overexpression promotes cell growth in NF2-positive GBM cells. (A) Proliferation analysis of Myc-tagged ezrin stably expressed in the NF2-positive LN229 …

WebJun 30, 2011 · Overexpression activated Erk1/2 in MiaPaCa-2 cells, which might be partially related to alterations in cell morphology and invasion . c-Myc induces cell invasion and anchorage-independent growth by regulating Ezrin protein expression in the presence of androgens, as the activity of the Ezrin promoter is controlled by androgens through c … albion park landscape suppliesWebOct 5, 2012 · Ezrin is a cytoskeletal protein that is involved in tumor growth and invasion. It has been suggested that Ezrin expression plays an important role in tumor metastasis. … albion park to corrimalWebMay 20, 2014 · Ezrin overexpression promotes cell migration and pulmonary metastasis To investigate the role of ezrin in the invasiveness and metastatic potential, we took the approach of overexpressing or decreasing ezrin in the human OS cell line MG63, which normally expressed background levels of ezrin protein. albion pa prison inmate lookupWebJan 24, 2013 · Background Ezrin is a member of the ezrin, radixin, and moesin family that provides a functional link between the plasma membrane and the cortical actin … albion park postcodeWebFigure 1 Ezrin induces pancreatic cancer cell proliferation.Notes: (A) Endogenous expression of Ezrin and YAP was detected in different pancreatic cancer cell lines by Western blot.(B) Efficiency of Ezrin knockdown in Capan-1 cells by siRNA was verified by Western blot.(C) Efficiency of Ezrin overexpression in BxPC-3 cells by plasmid … albion partners llcWebMar 23, 2024 · The overexpression of ezrin protein would promote the worsening of tumors . Several studies disclosed that ezrin proteins play an important role in the development of cancer ( 23 ). For example, in patients with osteosarcoma, ezrin protein expression level in vivo is higher than normal. albion partners albion pc620000