WebSuperPathway Name Genes Count Relevance Score; 1: DREAM Repression and Dynorphin Expression: 250: 0.452 WebFurther analysis by immunofluorescence showed that EML4 was required for the organization of the mitotic spindle and for the proper attachment of kinetochores to microtubules. We searched for EML4-associating proteins by mass spectrometry analysis and found that the nuclear distribution gene C (NUDC) protein, which is a critical factor …
Reactome EML4 and NUDC in mitotic spindle formation
WebIn the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, … the wetbacks
WD40 domains of EML4 and the C-terminus of NUDC are …
WebNecessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). ... Localizes to the mitotic spindle in a EML4-dependent manner (By similarity). By similarity Keywords ... Interacts with PLK1, PAFAH1B1 and DCDC1. Part of a complex containing PLK1, NUDC, dynein and dynactin (By similarity). Interacts ... WebJun 3, 2024 · In addition, cells expressing EML4-ALK V3 exhibit loss of spindle assembly checkpoint control that is at least in part dependent on ALK catalytic activity. Finally, we demonstrate that cells expressing EML4-ALK V3 have increased sensitivity to microtubule poisons that interfere with mitotic spindle assembly, whereas combination treatment … Web7 Pathways in the EML4 and NUDC in mitotic spindle formation SuperPath. Mitotic … the weta