WebAug 1, 2014 · The switch from cytoprotective to cytostatic autophagy induced by radiation in non-small cell lung cancer cells. We have recently identified the conversion of autophagic function from the cytoprotective form with radiation alone to a cytostatic form with radiation + vitamin D (or a vitamin D analog) in non-small cell lung cancer (NSCLC) cells [4]. WebMar 28, 2024 · Overall, SLLN-15 induces a dose-dependent anti-proliferative activity in the TNBC cell lines by the induction of autophagy and autophagic flux. The authors concluded that this induction is associated with a selective inhibition of AKT-MTOR signaling. In vivo, SLLN-15 (30mg/kg, PO, 3 times a week) inhibits the growth of TNBC in animal TNBC cell ...
A novel cytostatic form of autophagy in sensitization of …
WebApr 14, 2024 · Autophagy is a highly conserved process that functions to transport cargos to the lysosome for recycling and cellular degradation in eukaryotes [].Autophagy not only serves to remove defective or damaged organelles and cellular components by self-digestion, as a catabolic mechanism, it recycles substrates required to sustain … WebNov 7, 2024 · As a survival response, cytoprotective autophagy enables tumor cells to evade apoptotic signals and become resistant to chemotherapy and radiotherapy. When cytoprotective autophagy is blocked, it can enhance the sensitivity of tumor cells to chemotherapy and increase apoptosis in cancer cells ( Ulasov et al., 2024; Xu et al., 2024 ). games online please
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WebAutophagy is also associated with cancer therapies, wherein autophagy has been identified to play four different roles, specifically cytoprotective, cytotoxic, cytostatic, and non-protective functions [Citation 12], although … WebMar 18, 2024 · Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. WebJul 31, 2016 · Our results revealed that autophagy induced by ivermectin has the capacity to inhibit breast cancer cell growth in a cytostatic way, suggesting that the use of … black gold waste oil furnace parts