WebJul 31, 2024 · General considerations; general procedure for the synthesis of substrates; optimization of the reaction conditions; general procedure for the asymmetric cyanotrifluoromethylation; scaled-up reaction; product transformations; mechanistic studies; characterization of products; single-crystal X-ray diffraction data for 3g; NMR spectra of … WebDec 16, 2014 · CONSPECTUS: The vicinal fluorofunctionalization of alkenes is an attractive transformation that converts feedstock olefins into valuable cyclic fluorinated molecules for application in the pharmaceutical, agrochemical, medical, and material sectors. The challenges associated with asymmetric fluorocy …
Asymmetric desymmetrization of alkene-, alkyne- and …
WebJul 3, 2024 · Asymmetric desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metal catalysis† Tao Shu and Janine Cossy * … WebNov 9, 2024 · Overview of the asymmetric switchable electrochemical transformations of alkenes. ( A) Electrogenerated α-keto radical species via nickel catalyst. ( B) Electrochemical alkene functionalization: type a, direct electrolytic activation of alkene; type b, direct electrolytic activation of reagent. try being my size
Symmetrical Alkyne - Chemistry LibreTexts
WebRhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes** Dr. Xiaoqiang Shen and Prof. Dr. Stephen L. Buchwald Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge MA ... provide good enantioselectivity for a range of terminal alkenes, but require a geminal dialkyl group7 to … WebJul 3, 2015 · The enantioselective hydroamination of alkenes has been successfully accomplished several times, albeit with a narrow substrate scope and/or moderate levels … WebDec 15, 2024 · Abstract. Aliphatic allylic amines are found in a great variety of complex and biorelevant molecules. The direct allylic C–H amination of alkenes serves as the most straightforward method toward these motifs. However, use of widely available internal alkenes with aliphatic amines in this transformation remains a synthetic challenge. philip stubbes anatomie of abuses